• 产品和服务

    一、 EV膜蛋白检测分析平台EVArray

    EVArray平台是基于免疫捕获的检测分析原理，无需EV提取、只需微量（ul）临床样本，即可实现EV膜蛋白高灵敏、高通量、高效率的检测与分析，应用于EV膜蛋白诊断标志物的开发。 

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    技术优势：

    ð 便捷：无需EV提纯，保留EV膜蛋白完整性

    ð 高灵敏度：只需微量临床样本（ul级）

    ð 高通量：可同时检测数百种EV膜蛋白

    ð 定制化：可针对不同疾病定制检测Panel，可同时进行总EV（Anti-CD63/CD9/CD81)和特定EV亚群（如L1CAM及其它定制化亚群）检测

     

    代表性文章

    杂志

    IF

    Dynamic Change of PD-L2 on Circulating Plasma Extracellular Vesicles as a Predictor of Treatment Response in Melanoma Patients Receiving Anti-PD-1 Therapy

    Journal of Extracellular Vesicles

    15.5

    Plasma extracellular vesicle derived protein profile predicting and monitoring immunthe-rapeutic outcomes of gastric cancer

    Journal of Extracellular Vesicles

    15.5

    Identification and validation of the surface proteins FIBG, PDGF-β, and TGF-β on serum extracellular vesicles for non-invasive detection of colorectal cancer: experimental study

    International Journal of Surgery

    15.4

    Efficacy and safety of immunotherapy combined with single-agent chemotherapy as second- or later-line therapy for metastatic non-small cell lung cancer

    Frontiers in Immunology

    5.7

    Surface proteome of plasma extracellular vesicles as mechanistic and clinical biomarkers for malaria

    Infection

    5.4

    Extracellular Vesicle Antibody Microarray for Multiplexed Inner and Outer Protein Analysis

    ACS Sens

    8.9

    Extensive surface protein profiles of extracellular vesicles from cancer cells may provide diagnostic signatures from blood samples

    Journal of Extracellular Vesicles

    15.5

    Exosomal Proteins as Diagnostic Biomarkers in Lung Cancer

    Journal of Thoracic Oncology

    20.4

     

    二、 高通量EV膜蛋白检测EVArray-SP400

    EVArray-SP400是基于EVArray技术平台开发的可同步检测430+种EV膜蛋白的通用型芯片产品，涉及多种疾病类型(如肿瘤、神经、心血管、骨代谢等)，适用于EV膜蛋白的高通量检测与筛选。

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    n 疾病类型：肿瘤、心血管、神经

    n 蛋白种类：EV膜蛋白、药物靶点、 酶类、细胞因子类

    n 参数：7个样本/芯片  

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    ð 联系我们，获取SP400详细检测列表。   

                    

    三、 EV膜蛋白糖基化检测平台EVArray-Lectin

    EV膜蛋白存在丰富的糖基化修饰，影响靶细胞对EV的摄取，以及EV的组织和器官分布 ，不同疾病或细胞来源EV膜蛋白具有特异性的糖基化修饰特征，可以作为疾病的的诊断标志物。

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    EVArray-Lectin平台是基于凝集素芯片进行总EV及其亚群膜蛋白糖基化的检测分析。 

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    技术优势：

    ð 微量样本：血浆/血清等临床样本100μL，EV样本1 μg

    ð 去除干扰：EVTMC进行EV提取，去除游离糖蛋白的干扰

    ð 定制化亚群：同步进行4种EV亚群膜蛋白糖基化检测，个性化定制不同EV亚群，例如常见的PDL1、EpCAM、CD36等

     

    代表性文章

    杂志

    IF

    Salivary adenoid cystic carcinoma-derived α2,6-sialylated extracellular vesicles increase vascular permeability by triggering ER-stress in endothelial cells and promote lung metastasis

    Cancer Letters

    9.7

    Lectins as potential tools for cancer biomarker discovery from extracellular vesicles

    Biomarker Research

    11.15

    Quantification-Promoted Discovery of Glycosylated

    Exosomal PD-L1 as a Potential Tumor Biomarker

    Small Methods

    12.49

    Assessment of Surface Glycan Diversity on Extracellular Vesicles by Lectin Microarray and Glycoengineering Strategies for Drug Delivery Applications

    Small Methods

    12.49

     

    四、 EV自身免疫抗体检测平台EVArray-AA

    EV可与自身抗体结合形成EV自身抗体复合物，作为疾病诊断的生物标志物。

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    EVArray-AA技术平台是利用噬菌体展示库和蛋白芯片进行EV自身免疫抗体检测与分析，适用于EV自身免疫抗体标志物开发。

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    代表性文章

    杂志

    IF

    Exosome autoantibody biomarkers for detection of lung cancer

    Military Medical Research

    16.7

    Autoantibody panel on small extracellular vesicles for the early detection of lung cancer

    Clinical Immunology

    8.67

     

    五、 EV(膜)蛋白质谱发现平台

    EV( 膜) 蛋白质谱发现平台可以同时实现EV总蛋白、 EV膜蛋白、EV-Cargo蛋白的质谱鉴定分析，全面提升低丰度EV膜蛋白的检出灵敏度与特异性，实现低丰度EV膜蛋白的高通量鉴定分析，获得全面的EV蛋白组信息。

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    代表性文章

    杂志

    IF

    Endothelial cell-derived extracellular vesicles expressing surface VCAM1 promote sepsis-related acute lung injury by targeting and reprogramming monocytes

    Journal of Extracellular Vesicles

    15.5

    Surface Proteome of Extracellular Vesicles and Correlation Analysis Reveal Breast Cancer Biomarkers

    Cancers

    5.28

    Exosomes harbor B cell targets in pancreatic adenocarcinoma and exert decoy function against complement-mediated cytotoxicity

    Nature Communications

    16.66

    Mitochondrial protein enriched extracellular vesicles discovered in human melanoma tissues can be detected in patient plasma

    Journal of Extracellular Vesicles

    15.5

    Surfaceome profiling enables isolation of cancer- specific exosomal cargo in liquid biopsies from pancreatic cancer patients

    Annals of Oncology

    50.56

     

    六、 EV膜蛋白鉴定验证平台

    免疫胶体金电镜是利用免疫胶体金标记技术结合透射电子显微镜来特异性识别、定位和观察外泌体或其表面特定抗原的一种高分辨率成像技术，是EV膜蛋白定性检测金标准。

     

     

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    EV-ELISA检测是通过EVTMC纯化试剂盒提取获得高纯度的EV样本，然后直接进行EV包被后，检测特定EV膜蛋白表达量的检测平台。

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    七、 EVTMC纯化试剂盒

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