• EV膜蛋白糖基化检测平台EVArray-Lectin

    EV膜蛋白存在丰富的糖基化修饰，影响靶细胞对EV的摄取，以及EV的组织和器官分布 ，不同疾病或细胞来源EV膜蛋白具有特异性的糖基化修饰特征，可以作为疾病的的诊断标志物。

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    EVArray-Lectin平台是基于凝集素芯片进行总EV及其亚群膜蛋白糖基化的检测分析。 

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    技术优势

    ð 微量样本：血浆/血清等临床样本100μL，EV样本1 μg

    ð 去除干扰：EVTMC进行EV提取，去除游离糖蛋白的干扰

    ð 定制化亚群：同步进行4种EV亚群膜蛋白糖基化检测，个性化定制不同EV亚群，例如常见的PDL1、EpCAM、CD36等

    代表性文章

    杂志

    IF

    Salivary adenoid cystic carcinoma-derived α2,6-sialylated extracellular vesicles increase vascular permeability by triggering ER-stress in endothelial cells and promote lung metastasis

    Cancer Letters

    9.7

    Lectins as potential tools for cancer biomarker discovery from extracellular vesicles

    Biomarker Research

    11.15

    Quantification-Promoted Discovery of Glycosylated Exosomal PD-L1 as a Potential Tumor Biomarker

    Small Methods

    12.49

    Assessment of Surface Glycan Diversity on Extracellular Vesicles by Lectin Microarray and Glycoengineering Strategies for Drug Delivery Applications

    Small Methods

    12.49